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专利名称：REAGENTS, COMPOSITIONS AND METHODS
FOR IMPROVING VIABILITY AND FUNCTIONOF CELLS, TISSUES AND ORGANS
发明人：DER SARKISSIAN, Shant,NOISEUX, Nicolas申请号：EP17812341.0申请日：20170615公开号：EP3471733A1公开日：20190424
摘要：Compounds, compositions and methods for improving the viability and/orfunction of cells or for the in vitro, ex vivo or in vivo protection of cells, tissue, graft ororgans from various damages are described. The reagents and composition are based onactivation of the heat shock response and/or the antioxidant response and include forexample, HSP90 co-factor inhibitor such as Celastrol or Celastrol analogs used alone orin combination with an adjunct agent (e.g., a NRF-2 activator, antioxidant, etc.). Therapeuticenhancement may also include increase in paracrine effector production and signaling.Methods for improving the resistance of cells, tissue, grafts or organs to damages orstress, such as hypoxic or oxidative stress-induced cell death, and/or for improving theviability and retention of transplanted or transfused cells are also described. Therapeutictreatment or prevention of ischemic injury (e.g. myocardial infarct, ischemia/reperfusioninjury) and related stressors (hypoxia, oxidative stress, inflammation, sepsis/ shock, etc)are also provided.
申请人：Der Sarkissian, Shant,Noiseux, Nicolas,VAL-CHUM, SOCIÉTÉ EN COMMANDITE
地址：4035 Rue Farrand Laval, Québec H7T 1S3 CA,4371 Rue Charlemagne Montréal,
Québec H1X 2H2 CA,3535, chemin Queen-Mary, bureau 220 Montréal, QC H3V 1H8 CA
国籍：CA,CA,CA
代理机构：Dehns
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