专利内容由知识产权出版社提供
专利名称：NANOPARTICULATE COMPOSITIONS OF
POORLY SOLUBLE COMPOUNDS
发明人：Maria Gonzalez Ferreiro,Christoph
Dunmann,Lutz Kroehne,Andreas Voigt
申请号：US13122501申请日：20091001
公开号：US20120058151A1公开日：20120308
摘要：The present invention relates to a method for the production of a
nanoparticulate pharmaceutical composition. The method comprises the steps of a)suspending in water a poorly soluble active ingredient without the presence of adetergent, b) mechanically treating said suspension to obtain particles comprising theactive ingredient with an effective average size of less than about 5000 nm, c) contactingsaid active ingredient or suspension with a first polyelectrolyte during and/or beforemechanically treating, d) optionally contacting said suspension with a one or more secondor further polyelectrolytes during, before and/or after mechanically treating, e)optionally drying said suspension. The invention also pertains to the pharmaceuticalcompositions obtained by the method of the invention.
申请人：Maria Gonzalez Ferreiro,Christoph Dunmann,Lutz Kroehne,Andreas Voigt
地址：The Hague NL,Berlin DE,Berlin DE,Berlin DE
国籍：NL,DE,DE,DE
更多信息请下载全文后查看
